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The M21 bus route constitutes a public transit line in Manhattan, New York City. The M21 operates between the West Village and the Lower East Side, serving as a Houston Street crosstown. The M9 and M21 are operated by the New York City Transit Authority, and based out of the Michael J. Quill Depot.
The transportation center is open 24 hours daily. Managed by the Niagara Frontier Transportation Authority (NFTA), which also uses the transit center as its headquarters, it operates as a major transportation hub for a number of NFTA Metro bus routes, as well as inter-city bus services.