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Regulatory B cells (Bregs or B reg cells) represent a small population of B cells that participates in immunomodulation and in the suppression of immune responses. The population of Bregs can be further separated into different human or murine subsets such as B10 cells , marginal zone B cells , Br1 cells, GrB + B cells, CD9 + B cells, and even ...
B cells, unlike the other two classes of lymphocytes, T cells and natural killer cells, express B cell receptors (BCRs) on their cell membrane. BCRs allow the B cell to bind to a foreign antigen, against which it will initiate an antibody response. B cell receptors are extremely specific, with all BCRs on a B cell recognizing the same epitope.
B10 cells are a sub-class of regulatory B-cells (B reg cell) that are involved in inhibiting immune responses in both humans and mice. [1] [2] [3] B10 cells are named for their ability to produce inhibitory interleukin: Interleukin-10 (IL-10). [4] [5] One of their unique abilities is that they suppress the innate and adaptive immune signals ...
In immunology, peripheral tolerance is the second branch of immunological tolerance, after central tolerance. It takes place in the immune periphery (after T and B cells egress from primary lymphoid organs ). Its main purpose is to ensure that self-reactive T and B cells which escaped central tolerance do not cause autoimmune disease. [1]
Regulatory B cells (Bregs) This page was last edited on 14 November 2019, at 15:07 (UTC). Text is available under the Creative Commons Attribution-ShareAlike License ...
BCGFs specifically mediate the growth and division of B cells, or, in other words, the progression of B cells through their life cycle (cell cycle stages G1, S, G2). BCDFs control the advancement of a B cell progenitor or unmatured B cell to an adult immunoglobulin (Ig) secreting cell.
Central tolerance is essential to proper immune cell functioning because it helps ensure that mature B cells and T cells do not recognize self-antigens as foreign microbes. More specifically, central tolerance is necessary because T cell receptors (TCRs) and B cell receptors (BCRs) are made by cells through random somatic rearrangement. [1]
List of PDB id codes. 2EO6. Identifiers. Aliases. BLNK, AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, bca, B-cell linker, B cell linker. External IDs. OMIM: 604515; MGI: 96878; HomoloGene: 32038; GeneCards: BLNK; OMA: BLNK - orthologs. Gene location ( Human) Chr.
Polyclonal B cell response. Polyclonal response by B cells against linear epitopes [1] Examples of substances recognized as foreign (non-self) Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping ...
B-cell receptor. The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell. A B-cell receptor includes both CD79 and the immunoglobulin. The plasma membrane of a B cell is indicated by the green phospholipids. The B- cell receptor extends both outside the cell (above the plasma membrane) and inside the cell (below the ...