Ads
related to: calcium channel blockers- Sign In
Sigma® Life Science
View contract pricing, get quotes
- Sigma® Life Science
Cell culture, antibodies
and more biological products
- Analytical/Chromatography
Browse our Analytical Reagents,
Standards, Microbiology and more.
- Classic Lab Chemicals
High-quality laboratory reagents.
Solvents, salts, acids, bases
- Order Center
Build a Shopping Cart, View Orders
Access ordering instructions
- Register an Account
Get product updates, special offers
Save favorites & shopping lists
- Sign In
Search results
Results from the Go Local Guru Content Network
Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium (Ca 2+) through calcium channels. Calcium channel blockers are used as antihypertensive drugs, i.e., as medications to decrease blood pressure in patients with hypertension.
Amlodipine is a long-acting calcium channel antagonist that selectively inhibits calcium ion influx across cell membranes. It targets L-type calcium channels in muscle cells and N-type calcium channels in the central nervous system which are involved in nociceptive signalling and pain perception.
Dihydropyridine calcium channel blockers are derivatives of 1,4-dihydropyridine that are used as L-type calcium channel blockers. They are used in the treatment of hypertension.
Nifedipine, sold under the brand name Procardia among others, is a calcium channel blocker medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor. It is one of the treatments of choice for Prinzmetal angina. It may be used to treat severe high blood pressure in pregnancy.
L-type calcium channel blockers are used to treat hypertension. In most areas of the body, depolarization is mediated by sodium influx into a cell; changing the calcium permeability has little effect on action potentials.
Channel blocking is conducted by different types of molecules, such as cations, anions, amino acids, and other chemicals. These blockers act as ion channel antagonists, preventing the response that is normally provided by the opening of the channel.
Ad
related to: calcium channel blockers