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Regulatory B cells (Bregs or B reg cells) represent a small population of B cells that participates in immunomodulation and in the suppression of immune responses. The population of Bregs can be further separated into different human or murine subsets such as B10 cells, marginal zone B cells, Br1 cells, GrB + B cells, CD9 + B cells, and even some plasmablasts or plasma cells.
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In 1989, Nelson cofounded BREG, another orthopedic company that achieved landmark success. BREG was sold in 2003 for $150 million. For the next few years, Nelson concentrated on other business opportunities and on philanthropic, faith-based, and community enhancement efforts. In 2007, Nelson became chairman and CEO of United Orthopedic Group ...
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It is currently unknown if Breg cell subsets are developmentally linked and how exactly differentiation into a Breg cell occurs. There is evidence showing that nearly all B cell types can differentiate into a Breg cell through mechanisms involving inflammatory signals and BCR recognition. B cell-related pathology
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