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Regulatory B cells (Bregs or B reg cells) represent a small population of B cells that participates in immunomodulation and in the suppression of immune responses. The population of Bregs can be further separated into different human or murine subsets such as B10 cells , marginal zone B cells , Br1 cells, GrB + B cells, CD9 + B cells, and even ...
B10 cells are a sub-class of regulatory B-cells (B reg cell) that are involved in inhibiting immune responses in both humans and mice. [1] [2] [3] B10 cells are named for their ability to produce inhibitory interleukin: Interleukin-10 (IL-10). [4] [5] One of their unique abilities is that they suppress the innate and adaptive immune signals ...
B cells, unlike the other two classes of lymphocytes, T cells and natural killer cells, express B cell receptors (BCRs) on their cell membrane. BCRs allow the B cell to bind to a foreign antigen, against which it will initiate an antibody response. B cell receptors are extremely specific, with all BCRs on a B cell recognizing the same epitope.
In immunology, peripheral tolerance is the second branch of immunological tolerance, after central tolerance. It takes place in the immune periphery (after T and B cells egress from primary lymphoid organs ). Its main purpose is to ensure that self-reactive T and B cells which escaped central tolerance do not cause autoimmune disease. [1]
Follicular B cell. Within the immune system, Follicular B cells (FO B cells) are a type of B cell that reside in primary and secondary lymphoid follicles (containing germinal centers) of secondary and tertiary lymphoid organs, including spleen and lymph nodes.
BCGFs specifically mediate the growth and division of B cells, or, in other words, the progression of B cells through their life cycle (cell cycle stages G1, S, G2). BCDFs control the advancement of a B cell progenitor or unmatured B cell to an adult immunoglobulin (Ig) secreting cell.
Plasma cells, also called plasma B cells or effector B cells, are white blood cells that originate in the lymphoid organs as B cells [1] [2] and secrete large quantities of proteins called antibodies in response to being presented specific substances called antigens.
List of PDB id codes. 2EO6. Identifiers. Aliases. BLNK, AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, bca, B-cell linker, B cell linker. External IDs. OMIM: 604515; MGI: 96878; HomoloGene: 32038; GeneCards: BLNK; OMA: BLNK - orthologs. Gene location ( Human) Chr.
Polyclonal B cell response. Polyclonal response by B cells against linear epitopes [1] Examples of substances recognized as foreign (non-self) Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping ...
V (D)J recombination (variable–diversity–joining rearrangement) is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation. It results in the highly diverse repertoire of antibodies/immunoglobulins and T cell receptors (TCRs) found in B cells and T cells, respectively.