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The M21 bus route constitutes a public transit line in Manhattan, New York City. The M21 operates between the West Village and the Lower East Side, serving as a Houston Street crosstown. The M9 and M21 are operated by the New York City Transit Authority, and based out of the Michael J. Quill Depot.
The M Queens Boulevard/Sixth Avenue Local is a rapid transit service in the B Division of the New York City Subway. Its route emblem, or "bullet", is colored orange since it is a part of the IND Sixth Avenue Line in Manhattan. The M operates at all times.