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The beta-1 adrenergic receptor (β 1 adrenoceptor), also known as ADRB1, can refer to either the protein-encoding gene (gene ADRB1) or one of the four adrenergic receptors. It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein that is expressed predominantly in cardiac tissue.
Beta-1 adrenergic receptors are the primary receptor of the heart and, therefore, autoantibodies to these receptors have been tied to many different heart diseases. Autoantibodies to beta1-adrenergic receptors are linked to chronic heart failure.
There are two main groups of adrenoreceptors, α and β, with 9 subtypes in total: α receptors are subdivided into α 1 (a G q coupled receptor) and α 2 (a G i coupled receptor) [7] α 1 has 3 subtypes: α 1A, α 1B and α 1D [a] α 2 has 3 subtypes: α 2A, α 2B and α 2C. β receptors are subdivided into β 1, β 2 and β 3.
MYmta is a mobile application-based passenger information display system developed by the Metropolitan Transportation Authority (MTA) of New York City. A beta version of the app was launched on July 2, 2018, and as of June 2019 [update] is still undergoing beta testing .
The cellphone-friendly website and "MYmta" app, currently in a beta test phase, show straphangers real-time subway, bus and commuter rail information that has been housed in separate apps.
Beta 1-adrenergic agonists, also known as Beta 1-adrenergic receptor agonists, are a class of drugs that bind selectively to the beta-1 adrenergic receptor. As a result, they act more selectively upon the heart. Beta-adrenoceptors typically bind to norepinephrine release by sympathetic adrenergic nerves and to circulating epinephrine.
An autoreceptor is a type of receptor located in the membranes of nerve cells. It serves as part of a negative feedback loop in signal transduction . It is only sensitive to the neurotransmitters or hormones released by the neuron on which the autoreceptor sits.
This page was last edited on 1 December 2007, at 08:14 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply.
Alpha-1 blockers (also called alpha-adrenergic blocking agents or alpha-1 antagonists) constitute a variety of drugs that block the effect of catecholamines on alpha-1-adrenergic receptors. They are mainly used to treat benign prostatic hyperplasia (BPH), hypertension and post-traumatic stress disorder. [1]
The melatonin receptors MT 1 and MT 2 are G-protein coupled receptors (GPCRs) that typically adhere to the cell's surface so that they can receive external melatonin signals. Binding of melatonin to the MT 1 receptor leads to inhibition of cAMP production and Protein Kinase A (PKA).